Why don't chromosomes alone determine every part of sex development?
Sex development involves chromosomes, genes, hormones, and the body's response to those hormones. Androgen insensitivity offers one example: differences in receptors can change how tissues respond to a signal. Explore how following that pathway explains more than reading a chromosome label alone.
Questions you could explore
- How does following a signal from a gene to a receptor change the explanation?
- How can differences in a hormone signal and differences in the response to that signal lead to different outcomes?
Start reading
- MedlinePlus Genetics / US National Library of MedicineAndrogen insensitivity syndrome
MedlinePlus explains how changes in the androgen receptor affect development in people with XY chromosomes. The example concerns physical development, not an inference about someone’s identity.
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