How can a tumor evolve while it grows?
A tumor contains related cells with different histories. Genetic changes can accumulate as those cells divide, leaving clues to which changes happened earlier and which appeared later. Researchers reconstruct that history from tumor samples, rather than watching every cell over a person’s lifetime.
Questions you could explore
- What would distinguish a new mutation from an existing cell lineage becoming more common?
Start reading
- National Cancer InstituteMapping Cancer Genomic Evolution Offers Insights into Tumor Development
NCI explains a 2020 genomic study that inferred the order of changes across tumor samples.
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