Are identical twins identical in every cell?
Identical twins begin with a shared developmental origin, but their cells keep dividing. Genetic changes can arise during those divisions and enter different cell lineages. Researchers can compare sampled DNA to investigate that history. Differences in DNA sequence, differences in gene activity, and differences in experience are separate explanations, even when they all contribute to how two people differ.
Questions you could explore
- What could DNA from one tissue tell you, and what would it leave unknown about the rest of the body?
Start reading
- Nature Genetics / Jónsson and colleagues; paper mirrored by GwernDifferences between Germline Genomes of Monozygotic Twins
Investigates genetic changes arising during early development, showing why a shared origin need not mean identical sampled DNA.
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